Lioness Messi and Christian Ronaldo to face in the draw for the Champions League round of 16 conducted on Monday.
Holders Chelsea has been paired against Lille in the first knockout round.
In other games, Manchester City will take on Villarreal, Salzburg face Liverpool and Juventus play Sporting Lisbon.
Real Madrid will clash with Benfica, Atletico Madrid take on Bayern Munich and Inter Milan face Ajax. Manchester United will face Paris Saint-Germain (PSG) .
This means we will see Lionel Messi take on Cristiano Ronaldo in continuation of their rivalry when both sides face each other in March 2022.
But remember, there are no longer away goals in the Champions League.
The first legs will be played across February 15/16 and 22/23, while the second legs will be played across March 8/9 and 15/16.
Draw in full:
Benfica vs Real Madrid
Villarreal vs Manchester City
Atletico vs Bayern Munich
FC Salzburg vs Liverpool
Inter Milan vs Ajax
Sporting vs Juventus
Chelsea vs Lille
PSG vs Manchester United